2015年1月18日 星期日

維他命D3能預防慢性呼吸疾病發作 Vitamine D3 reduces exacerbation of COPD

維他命D3能預防慢性呼吸疾病發作

Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial

The vitamin was given in bolus doses of 3 mg (120,000 IU) six times, 2-monthly, over the course of a year.

including the fact that 87%, in total, had a vitamin D deficiency, defined as serum 25-hydroxyvitamin D levels less than 75 nmol/L, at baseline.

baseline vitamin D deficiency affected the time to exacerbation or infection and found that patients with baseline levels of less than 50 nmol/L had a reduced risk for moderate or severe exacerbation (AHR, 0.57; 95% CI, 0.35 - 0.92; P = .021) with vitamin D administration.

http://www.thelancet.com/…/PIIS2213-2600%2814%2970…/abstract
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